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MyMD Pharmaceuticals Enrolls First Client in Stage 2 Medical Test of MYMD-1 as a Therapy for Delaying Aging and Expanding Healthy And Balanced Lifespan

by Penny Roberts
March 20, 2022

MyMD Pharmaceuticals, Inc. (Nasdaq: MYMD) (” MyMD” or “the Firm”), a professional phase pharmaceutical firm dedicated to prolonging healthy and balanced life expectancy, today revealed that the very first patient has been signed up in the Firm’s Stage 2 scientific test of lead prospect MYMD-1, a dental immune regulator drug, as a therapy for postponing aging and also expanding healthy and balanced life expectancy.

The main endpoint for the Stage 2 double-blind, placebo-controlled professional test is to attain a decrease in the flowing levels of (TNF-α), growth death aspect receptor I (TNFRI) and also IL-6. TNF-α and also IL-6 are the proteins in the body that cause swelling and aid trigger the process of aging. The additional procedures of the trial will be the security, tolerability, and also pharmacokinetics in this populace of clients.

” In a Phase 1 medical test of MYMD-1, we showed the medicine’s statistically considerable efficacy in minimizing levels of TNF-α, a key player in triggering pathological aging, in the blood. The FDA has authorized TNF-α decrease as the primary endpoint for our Stage 2 research, which we believe settings us well for a successful Phase 2 end result,” claimed Chris Chapman, M.D., Head Of State, Director and Principal Medical Officer of MyMD. “The initiation of patient registration in this study advances our mission to slow down the aging process, prevent loss of muscle mass tissue in aging, restriction frailty, as well as prolong healthy and balanced life-span.”

MyMD has actually stated that there are no FDA-approved drugs for dealing with aging disorders and prolonging healthy and balanced lifespan humans, a market expected to be at the very least $600 billion by 20251 according to a major investment bank. TNF-α blockers are one of the most prescribed medicines by income, a worldwide market of around $40 billion per year,2 and, according to Nature Aging journal,3 a downturn in aging that would certainly raise life span by one year deserves $38 trillion as well as by 10 years deserves $367 trillion.

Along with aging, MYMD-1’s distinct action in managing the immune system and also dealing with chronic inflammation is being established for the therapy of autoimmune condition, including rheumatoid joint inflammation (RA), several sclerosis (MS), diabetes mellitus, and also inflammatory digestive tract condition.

” We plan to begin writing procedures for a Phase 2 pilot research of MYMD-1 for rheumatoid arthritis early this year,” Dr. Chapman kept in mind. “The increasing prevalence of rheumatoid arthritis as well as other autoimmune as well as inflammatory diseases are driving need for TNF inhibitors like MYMD-1, and also we believe our orally provided drug with very low toxicity would be disruptive to the $60 billion market for RA if authorized by the FDA for this indicator.”

Rheumatoid joint inflammation influences approximately 40 million people globally.4.

Regarding MYMD-1.

Initially created for autoimmune conditions, MYMD-1’s key purpose is to reduce the aging procedure, avoid sarcopenia and also frailty, as well as prolong healthy lifespan. Since it can cross the blood-brain barrier and get to the main nerves (CNS), MYMD-1 is additionally positioned to be a feasible treatment for brain-related problems. Its device of action as well as efficiency in diseases including multiple sclerosis (MS) and also thyroiditis have actually been studied with cooperations with numerous academic institutions. MYMD-1 is likewise revealing guarantee in pre-clinical studies as a potential therapy for message- COVID-19 difficulties and as an anti-fibrotic as well as anti-proliferation healing.

MYMD-1 has revealed efficiency in pre-clinical researches in controling the immune system by carrying out as a discerning prevention of growth death factor-alpha (TNF-α), a vehicle driver of chronic inflammation. Unlike various other therapies, MYMD-1 has actually been displayed in these pre-clinical researches to selectively obstruct TNF-α when it becomes overactivated in autoimmune conditions and cytokine tornados, however not block it from doing its normal job of being an initial responder to any kind of routine type of moderate infection. MYMD-1’s ease of dental dosing is an additional differentiator compared to currently available TNF-α blockers, all of which call for distribution by injection or mixture. No accepted TNF inhibitor has actually ever been dosed orally. In addition, the medicine is not immunosuppressive as well as has actually not been shown to cause the serious side effects typical with typical therapies that treat swelling.

Concerning MyMD Pharmaceuticals, Inc

. MyMD Pharmaceuticals, Inc. (Nasdaq: MYMD), a professional stage pharmaceutical firm dedicated to extending healthy lifespan, is concentrated on establishing two novel restorative systems that treat the causes of illness as opposed to just dealing with the signs and symptoms. MYMD-1 is a drug platform based on a professional phase little particle that regulates the immune system to control TNF-α, which drives persistent swelling, and other pro-inflammatory cell signaling cytokines. MYMD-1 is being developed to delay aging, rise longevity, and treat autoimmune conditions and COVID-19- connected clinical depression. The Business’s 2nd medicine platform, Supera-CBD, is being created to treat persistent discomfort, dependency as well as epilepsy. Supera-CBD is an unique artificial derivative of cannabidiol (CBD) and also is being established to address and also improve upon the rapidly growing CBD market, that includes both FDA approved medicines and also CBD products not currently regulated as medications. For more details, browse through www.mymd.com.

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